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NEJM -- Celecoxib for the Prevention of Sporadic Colorectal Adenomas Original Article from The New England Journal of Medicine -- Celecoxib for the Prevention of Sporadic Colorectal Adenomas.
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Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and ...Celecoxib (10-5 molL) reduced activation of c-jun terminal NH2 kinase (JNK), whereas it did not affect p38 mitogen-activated protein (MAP) kinase or p4442 ...Drs. Paul Moore and Elliott Hersh should be complimented on their review of celecoxib and rofecoxib for including the basic science, as currently understood ...
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